Aging is the most universal phenomenon in nature, experienced by every living system on Earth.
For most organisms, aging is the central driver of death and disease.
However, there is extreme variation in the rate at which living systems decline, suggesting aging is malleable.
Our lab seeks to discover mechanisms of aging that can be targeted to delay or prevent disease.
The Levine lab bridges bioinformatics and experimental approaches.
Bioinformatics (Dry Lab): The bioinformatics team develops and applies advantaged computational methods to generate quantitative estimates of biological aging, or identify key molecular factors that may regulate aging. Building on this, we also seek to map multi-dimensional trajectories of cells, tissues, and organs as they move through time.
Experimental (Wet Lab): The molecular biology team uses in vitro and in vivo experiments to identify drivers of cellular aging and test efficacy of interventions aimed at modifying or reversing age-related changes.